© Zack Jarosz
September 15, 2025
Lena Sämann
The phenomenon "Ozempic Face" describes the noticeable facial loss that can occur with rapid weight loss through GLP-1 agonists like Ozempic. We explain what's behind it and how the effects can be minimized.
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The rapid weight loss through GLP-1 receptor agonists like Ozempic has brought an unwanted side effect into focus: the so-called "Ozempic Face." This term describes the characteristic facial changes that can occur with rapid weight reduction. What exactly is behind this phenomenon and how can it be avoided?
"Ozempic Face" is a term used by doctors and patients to describe the visible changes in the face caused by rapid weight loss. The face appears gaunt, the cheeks seem hollow, and the skin can become saggy. Areas particularly affected are often around the eyes, cheeks, and chin area.
The term originated in connection with the use of semaglutide (Ozempic, Wegovy) and other GLP-1 receptor agonists for weight reduction. It is important to understand, however, that it is not the medication itself causing these changes, but the rapid weight loss.
The human face contains various fat pads that contribute to a youthful and full appearance. These fat deposits are located in different areas:
With rapid weight loss, these fat reserves are quickly depleted, leading to the characteristic changes in the face.
In addition to fat loss, skin texture also plays an important role. The skin needs time to adjust to new body proportions. With too rapid a weight reduction, the skin cannot keep up and appears loose or wrinkled.
Certain factors increase the risk of pronounced facial changes:
As we age, the skin naturally loses elasticity. People over 40 are therefore more often affected by pronounced facial changes because their skin is less responsive to volume changes.
The faster the weight loss, the more pronounced the facial changes can be. A weight reduction of more than 1-2 kilograms per week significantly increases the risk.
People with originally rounder facial features or certain genetic predispositions may experience more significant changes.
The most important preventive measure is a controlled, not too rapid weight loss. Experts recommend a weekly weight reduction of 0.5 to 1 kilogram to give the skin time to adjust.
A consistent Skin care can improve skin quality:
Regular facial massages can promote blood circulation and support skin firmness. Specific facial exercises can also be helpful.
Various non-surgical treatment options are available for changes that have already occurred:
Hyaluronic acid fillers: Can restore volume in hollowed areas and provide a more youthful appearance.
Collagen-stimulating treatments: Procedures like microneedling or radiofrequency treatments can stimulate the body's own collagen production.
Thread lifting: Minimally invasive method for tightening sagging skin areas.
In severe cases, surgical procedures such as a facelift may be considered. However, this option should only be considered after weight stabilization and careful consideration.
Professional medical supervision is essential when using GLP-1 agonists for weight loss. Your doctor can:
Changes in the face can have significant psychological impacts. Those affected often report:
A psychological support can be helpful in such cases to cope with the changes and develop realistic expectations.
The good news is that many of the facial changes may partially reverse over time. The skin gradually adapts to the new proportions, and with increasing age the facial features can develop more harmoniously again.
The phenomenon "Ozempic Face" should be considered when deciding on drug-induced weight loss. While the health benefits of weight loss in cases of severe obesity usually outweigh the risks, thorough education about possible aesthetic side effects is important.
A slow, controlled weight reduction under medical supervision, combined with preventive measures for skin health, can significantly reduce the risk of pronounced facial changes. If changes have already occurred, various treatment options are available to improve appearance.
The decision for GLP-1 therapy should always be made individually and after thorough medical consultation, taking all aspects of the treatment – including possible aesthetic impacts – into account.
