Find a DoctorSearch the network for suitable specialists and contact them directly
© Freepik
August 11, 2025
Lena Sämann
- Aesthetic Surgery & Dermatology
- Beauty
Hyaluronic Acid: The Ultimate Guide for Healthy and Fresh Skin
All about hyaluronic acid, the anti-aging agent that binds up to 6,000 times its weight in water, instantly giving your skin more moisture and elasticity.
What is hyaluronic acid? Definition and basics
Hyaluronic acid is a naturally occurring substance in the human body that plays a central role in skin health . This endogenous substance belongs to the glycosaminoglycans and is particularly known for its extraordinary ability to bind large amounts of water – up to 6,000 times its own weight.
Hyaluronic acid is mainly found in the skin, joints, eyes, and connective tissue. With increasing age but the body's own production continuously decreases, leading to visible signs of skin aging.
How does hyaluronic acid work? The science behind it
Moisture retention and skin tightening
The main mechanism of action of hyaluronic acid is based on its molecular structure. The long chains of this substance can store large amounts of water between their molecules, creating a gel-like state. This property makes it a natural moisture reservoir for the skin.
Collagen production and elasticity
Modern research shows that hyaluronic acid not only moisturizes but also stimulates collagen production. Collagen is the structural protein responsible for the firmness and elasticity of the skin.
Different forms of hyaluronic acid
High molecular weight hyaluronic acid
High molecular hyaluronic acid forms a protective film on the skin's surface and prevents moisture loss. This form is particularly suitable for external use in creams and serums.
Low molecular weight hyaluronic acid
Low molecular variants can penetrate deeper into the skin and develop their moisturizing effect there. They are especially found in anti-aging products popular.
Oligo-hyaluronic acid
The smallest form of hyaluronic acid can penetrate into the deeper layers of the skin and act specifically there.
Hyaluronic acid in cosmetics: application and products
Hyaluronic acid serum
Serums with hyaluronic acid are particularly concentrated care products that are applied before the moisturizer. They absorb quickly and provide the skin with intensive moisture.
Hyaluronic acid cream
Moisturizers with hyaluronic acid are suitable for daily care and offer long-lasting protection against drying out.
Hyaluronic acid masks
Face masks with this active ingredient provide intensive instant care and are ideal for weekly intensive treatments.
Medical applications of hyaluronic acid
Wrinkle injections
In aesthetic medicine, hyaluronic acid is often used for wrinkle treatment Targeted injections can smooth expression lines and restore volume.
Joint treatment
In osteoarthritis, hyaluronic acid is injected directly into the affected joint Injected to improve joint fluid and relieve pain.
Ophthalmology
In ophthalmology it is used as a component of eye drops for dry eyes or as an aid in surgeries.
Benefits of hyaluronic acid for the skin
Intensive moisture supply
The main advantage is the exceptional ability to bind moisture. This results in a plumper, smoother skin appearance.
Anti-aging effect
By stimulating collagen production and intensive moisture supply, fine lines are reduced and skin elasticity is improved.
Improvement of the skin barrier
Hyaluronic acid strengthens the skin's natural protective barrier, making it more resistant to environmental influences.
Soothing effect
The substance has anti-inflammatory and soothing effects, making it suitable for sensitive skin.
Side effects and tolerability
Cosmetic application
In topical application in cosmetic products, side effects are very rare. Occasionally, slight skin irritations may occur, especially in very sensitive skin.
Medical treatments
Injections may cause temporary swelling, redness, or bruising. Serious side effects are very rare when used properly.
How to use hyaluronic acid correctly: Tips and tricks
The correct order
Hyaluronic acid products should be applied to clean, slightly damp skin. Then use a moisturizer to enhance the effect.
Combination with other active ingredients
Hyaluronic acid can be well combined with other anti-aging agents such as vitamin C, retinol, or niacinamide.
Morning vs. evening application
The application is possible both in the morning and evening. In the morning, it provides protection against environmental influences, and in the evening, it supports nightly regeneration.
Hyaluronic acid vs. other anti-aging agents
Hyaluronic acid vs. collagen
While collagen strengthens the skin structure, hyaluronic acid focuses on moisturizing. A combination of both agents can achieve synergistic effects.
Hyaluronic acid vs. retinol
Retinol stimulates cell renewal but can be irritating. Hyaluronic acid, on the other hand, soothes and moisturizes, which is why the two active ingredients complement each other.
Natural ways to boost the body's own production of hyaluronic acid
Nutrition
A balanced diet with enough vitamin C, zinc, and magnesium can support the body's own production.
Lifestyle
Adequate Sleep, Stress reduction and avoiding smoking promote the natural regeneration of the skin.
Dietary supplements
Hyaluronic acid capsules can replenish the body's reserves from within.
Buying guide: What to consider when buying?
Molecular size
Look for products with different molecular sizes for optimal effect in all layers of the skin.
Concentration
A concentration of 0.1 to 2 percent is optimal for cosmetic products.
Additional ingredients
Combinations with vitamin E, aloe vera, or panthenol can enhance the effect.
Packaging
UV-impermeable packaging protects the sensitive substance from decomposition.
Cost and economy
Prices for hyaluronic acid products vary greatly depending on concentration, brand, and product type. While inexpensive creams are available from 10 euros, high-quality serums can cost 50 euros or more. In medical treatments, the costs range between 300 and 800 euros per session.
Conclusion: Hyaluronic acid as the key to healthy skin
Hyaluronic acid has established itself as one of the most effective and well-tolerated anti-aging active ingredients. Its versatility in application – from daily skincare to medical treatment – makes it an indispensable component of modern skincare. The scientifically proven efficacy and good tolerance speak for a regular application as part of a comprehensive anti-aging strategy.
Investing in high-quality hyaluronic acid products is a worthwhile measure for anyone who wants to keep their skin healthy and youthful. With consistent use, visible improvements in moisture, elasticity, and overall skin appearance can be seen after just a few weeks.
