
© Freepik
The combination of whey and collagen can be an effective means to improve both muscle mass and the structural integrity of muscle tissue.
June 11, 2025
Nils Behrens
Nils Behrens is a top expert in the fields of holistic medicine and prevention and host of the podcast "Healthwise." In his current column, he explains why the combination of whey and collagen can revolutionize your muscle tissue and ensure long-term health.
Protein Power 2.0! A new study shows: The combination of whey protein and collagen not only boosts muscle growth but also promotes connective tissue synthesis – a real gamechanger for recovery, prevention and performance.
In the world of sports nutrition, much revolves around optimal muscle growth. But what about connective tissue that stabilizes and protects our muscles? A recent study sheds light on the subject and shows that the combination of 25 g of whey protein with 5 g of collagen not only strengthens the myofibrils (the contractile elements of muscles) but also significantly increases the synthesis of muscle connective tissue—at least during rest phases.
28 healthy, active men with an average age of 25 participated in a randomized, double-blind study. After a leg workout, they received either the protein mix or a placebo. Over a period of five hours, blood samples and muscle biopsies were taken to measure synthesis rates of myofibrillar and connective tissue proteins.
The intake of the whey-collagen mix led to a significant increase in myofibrillar protein synthesis in both trained and untrained leg muscles. Interestingly, an increased synthesis of muscle connective tissue was also observed in untrained muscles—a phenomenon not previously seen with whey intake alone. However, in trained muscles, this effect was not significant, indicating the complex interaction between training and nutrient uptake.
Connective tissue is not just filler material – it plays a crucial role in power transmission, stability and injury prevention. Well-developed connective tissue can boost performance and reduce the risk of muscle injury. Therefore, the combination of whey and collagen could be an effective means to improve both muscle mass and the structural integrity of muscle tissue.

Top health expert and PMC columnist Nils Behrens
Whey protein is rich in essential amino acids, particularly leucine, which is considered the key amino acid for muscle protein synthesis. Collagen, on the other hand, provides high amounts of glycine and proline, which are essential for the synthesis of connective tissue proteins. The combination of both proteins appears to work synergistically, promoting both muscle and connective tissue protein synthesis.
Integrating just 5g of collagen into a whey protein meal can offer significant advantages for muscle and connective tissue health. This simple dietary adjustment could make a big difference in training adaptation, recovery, and long-term health.
Nils Behrens is the Chief Brand Officer of Sunday Natural and host of the HEALTHWISE podcast. He also teaches as a lecturer at the Fresenius University of Applied Sciences, where he is a sought-after health expert. Previously, Behrens worked for over 12 years as the Chief Marketing Officer of the Lanserhof Group and host of the successful 'Forever Young' podcast.

A single hydrogel injection into the knee may relieve osteoarthritis pain for years. Orthopedist Dr. Ivo Breitenbacher has treated around 200 patients with it and explains who the procedure is right for and where its limitations lie
Christine Bürg & Marianne Waldenfels

An interview with
Dr. med. Ivo Breitenbacher

Almost everyone has seen them, and most people ignore them: tiny specks and strands drifting across their vision. Usually, they’re harmless. But sometimes they signal an emergency where quick action can save your sight. Ophthalmologist Dr. Mirka Höltzermann explains which warning signs to watch for.
Christine Bürg & Marianne Waldenfels

An interview with
Dr. Mirka R. Höltzermann

Can fasting relieve hot flashes and other menopausal symptoms? Dr. Verena Buchinger-Kähler shares remarkable cases from her clinical practice and explains how women respond to prolonged fasting – and what science has revealed so far.
Christine Bürg & Marianne Waldenfels
An interview with
Dr. med. Verena Buchinger

"Feel good, live better" – in this episode, Dr. Alexandra Schoeneich sheds light on the wide-ranging changes that menopause brings to the body
Christine Bürg

An interview with
Dr. med. Alexandra Schoeneich

Stopping antidepressants can trigger symptoms that resemble a return of depression. Psychiatrist Prof. Dr. Andreas Menke explains how to tell the difference, why the final milligrams can be particularly difficult, and which two mistakes patients should avoid.
Christine Bürg & Marianne Waldenfels

An interview with
Prof. Dr. med. Andreas Menke