Cordyceps effects on hormones: How cortisol, testosterone, and estrogen could be influenced

Hormone Compass Body: Where Cordyceps Potentially Involves

Hormones control a lot: they influence our mood, metabolism and even the immune system. It is all the more exciting that Cordyceps sinensis is increasingly being discussed in research as a possible regulator of these complex hormonal processes.

Initial indications suggest that ingredients such as cordycepin, polysaccharides and sterols could interfere with hormonal control circuits: directly, for example by stimulating the production of estrogen or testosterone, or indirectly through anti-inflammatory and stress-regulating effects.

The following sections highlight how cordyceps may potentially affect various hormonal axes in the body - from testosterone synthesis to stress hormone cortisol to the female cycle.

What is Cordyceps?

Cordyceps sinensis - also known as Chinese caterpillar fungus - is a traditional vital mushroom from the Tibetan highlands. In TCM it has been considered a tonic for energy and vitality for centuries. Today it is mostly used as an extract or capsule – with exciting ingredients and modern potential.

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Cordyceps & Testosterone: Natural potential for energy and vitality?

In traditional Chinese medicine, Cordyceps has long been considered a herbal supporter of male vitality. Its possible effect on testosterone production makes the vital mushroom interesting to this day.

The thesis: Cordyceps could stimulate the body's own hormone formation - via the luteinizing hormone (LH), which controls testosterone production in the testes. In addition, the mushroom could improve oxygen supply and support endurance - particularly relevant for Athletes.

But how sound are these statements?

Cordyceps is associated with a possible stimulation of the luteinizing hormone (LH), which stimulates testosterone production in the testes. 

Cordyceps and male hormone formation: What studies show

• A clinical study from 2011 examined the effect of Cordyceps sinensis on testosterone levels in healthy young men. Over eight weeks, participants received either 2.4 g of Cordyceps powder or a placebo. The result: There was no significant difference between the groups. Neither testosterone levels nor strength values significantly improved through intake - at least under these conditions.
• The situation is different at the cellular level: A in vitro study from 2024 investigated isolated Leydig cells and found that a Cordyceps sobolifera extract significantly increased cell proliferation and testosterone secretion. The researchers attribute this to an activation of the cAMP-PKA signaling pathway and a change in cholesterol metabolism - both key factors for hormone formation. Although cell studies provide important initial clues, a positive effect on isolated cells does not automatically mean that these results will also appear in humans.
• It therefore becomes interesting when a substance works not only in the test tube but also in the living organism. This is exactly what a combined in vitro and in vivo study from 2003 showed: In mice, Cordyceps sinensis could significantly increase testosterone production both in isolated Leydig cells and in the blood of the animals. Such in vivo models are considered methodologically more meaningful than pure cell studies - and strengthen the hope that similar effects might one day be confirmed in humans.

Cordycepin - Activator of Steroid Production

Cordycepin, a natural component of the Cordyceps mushroom, acts directly on hormone-producing cells. It activates the so-called cAMP-PKA signaling pathway, which plays a key role in the production of steroid hormones such as testosterone. In short: Cordycepin sets the hormonal machinery in motion - at least in the lab.

Cordyceps & Cortisol: Gentle support during constant stress?

Cortisol – also known as the stress hormone – is a true survival helper: It quickly mobilizes energy, sharpens our senses, and boosts metabolism when it matters. In the short term, this is a fantastic invention of nature. However, if cortisol levels remain permanently elevated, for example due to chronic Stress, it can significantly strain the body and psyche .

Cordyceps as a natural adaptogen for stress? 

In naturopathy, Cordyceps is considered an adaptogen – a plant-based helper intended to support the body in better handling stress.. Unlike traditional sedatives or stimulants, adaptogens are not supposed to dampen or amplify the hormonal stress response but to balance it finely – depending on what the body needs at the moment.

But does it really work? Initial scientific studies have long been examining this effect – with exciting approaches.

Activating impulses of the vital mushroom

As early as 1998, an early laboratory study indicated that Cordyceps sinensis can stimulate the production of corticosterone – the animal equivalent to human cortisol – in hormone-producing cells. Researchers speculated that this could explain the invigorating effects of the mushroom, as described in traditional applications, for instance, to enhance performance or in sports: a targeted, short-term increase of the stress hormone – comparable to a “positive” stress impulse that activates the body without burdening it.

Cordyceps as an inflammation regulator

New research from the year 2025 suggests that Cordyceps sinensis not only has an activating effect but also a balancing one – especially in stress-induced inflammations. In a laboratory study with human cells, the mushroom extract inhibited the production of inflammation-promoting messenger substances.

This is particularly exciting because persistent inflammation can keep the body's stress system - the so-called HPA axis - in a constant state of alertness. The result: permanently elevated cortisol levels. Cordyceps could help calm these processes and support hormonal balance.

Even though there are no studies on humans so far, the research provides a promising initial indication.

What do polysaccharides do?

Polysaccharides from Cordyceps are associated in studies with positive effects on the immune system and inner balance. They could help to mitigate stress-related Inflammatory reactions to alleviate.

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Cordyceps & Estrogen: What Cordyceps could do in the female body

Hormonal fluctuations are part of many women's lives - especially around the Menopause. When estrogen levels drop, it can have far-reaching consequences: From mood swings to skin changes to decreasing bone density.

What does science say?

• Already in 2004, a cell study investigated how Cordyceps affects human ovarian cells. The researchers found that Cordyceps activates certain proteins in the cells that help produce estrogen. Particularly important are two 'switches': One ensures that cholesterol, the fundamental building block for hormones, reaches the cell correctly. The other converts it into estrogen.
• An animal study from 2014 showed: In rats without ovaries, a model for estrogen deficiency, Cordyceps increased estradiol levels, improved bone health, and reduced inflammation as well as degradation enzymes such as ALP and TRAP. The researchers speak of a mild, estrogen-like effect.

Even though clinical studies in humans are still lacking, these results open up new perspectives on Cordyceps as a natural companion in hormonal transition phases.

Cordyceps isoflavones: gentle helpers for hormone balance

The vital mushroom contains isoflavones - plant substances that are similar to the body's own estrogen. They bind to the same receptors but exert a weaker effect, thus providing gentle hormonal 'fine-tuning'.

By the way: Testosterone also plays an important role in women's health. How Cordyceps could support here, you can read in the article on Cordyceps effects in women.

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Many women suffer from stress, hormonal fluctuations, and energy loss in everyday life. A natural way to enhance well-being? Taking medicinal mushrooms like Cordyceps. But what can the exotic mushroom really do for women's health? Modern research provides exciting answers.

What role does the thyroid play? 

The thyroid may be only fist-sized, but it controls central bodily functions through its hormones T3 and T4 – from metabolism and body temperature to energy, mood, and heartbeat. It can be thought of as a sensitive control panel that communicates closely with the brain – via the so-called hormonal axis between hypothalamus, pituitary gland, and thyroid.

So when we talk about the effects of Cordyceps on hormones, the thyroid is almost always included – even if it is not explicitly mentioned. Because hormonal processes are interconnected, substances like cordycepin or polysaccharides could also influence thyroid function through their stress- and inflammation-regulating effects.

Cordyceps in everyday life: How the mushroom can help with hormonal issues

Whether it's energy slumps, cycle chaos, or mood swings – many people are turning to Cordyceps for hormonal unrest nowadays. Usually in the form of capsules or extract powder, the recommended daily dose according to manufacturers is 1000 to 2000 mg – ideally in the morning or at noon when the body could use a little push. Particularly popular: combinations with other vital mushrooms such as Reishi (for inner calm) or Maitake (cycle companion with tradition).

Sounds promising – and initial studies at the cellular level or in animal models indeed confirm hormonal effects. But it's also clear: Research in humans is still in its infancy. Cordyceps is (still) not a miracle cure – rather a herbal stimulator that needs to be used mindfully.

Our tip? Listen to your body, seek advice if in doubt – and see Nutritional supplement not as a substitute for medical treatment, but as part of a holistic, individualized lifestyle.

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