Vaccinations for Long-Distance Travel: The Guide to Safe Traveling

© Freepik

July 25, 2025

Lena Sämann

  • Travel

Vaccinations for Long-Distance Travel: The Guide to Safe Traveling

Which vaccination is needed for which country? When should one start with the vaccination? This guide provides information according to STIKO.

Why are travel vaccinations important?

Traveling to tropical and subtropical areas can expose you to pathogens that are rare or nonexistent in Germany. Travel vaccinations not only protect you but also prevent the importation of dangerous infectious diseases to Germany. Timely vaccination advice is therefore an essential part of any travel preparation.

An overview of the most important travel vaccinations

Check standard vaccinations before long-distance trips

Before you receive special travel vaccinations, all standard vaccinations should be up to date according to STIKO recommendations:

  • Tetanus/Diphtheria/PertussisEvery 10 years booster
  • Measles/Mumps/Rubella (MMR)Especially important for those born after 1970
  • PoliomyelitisBooster for travel to risk areas
  • InfluenzaAnnual vaccination recommended

Mandatory vaccinations for certain countries

Yellow fever vaccination

Yellow fever vaccination is required for entry into many African and South American countries. The international vaccination certificate must be presented upon entry.

Important facts:

  • Vaccination at least 10 days before departure
  • Protection lasts for life
  • Only possible at authorized yellow fever vaccination centers

Meningococcal vaccination

For pilgrimage trips to Saudi Arabia (Hajj/Umrah), a meningococcal vaccination (ACWY) is mandatory.

Recommended travel vaccinations by destination

Hepatitis A and B

Hepatitis A is one of the most common travel-related infections and is transmitted through contaminated food and water transmitted.

Hepatitis B is transmitted through body fluids and is particularly relevant for longer stays or high-risk activities.

  • Hepatitis A: Protection after 2-4 weeks, booster after 6-12 months
  • Hepatitis B: Primary immunization with 3 vaccinations over 6 months
  • Combination vaccine available

Typhoid

Typhoid is spread by contaminated food and water transmission occurs particularly in South Asia, Africa, and Latin America.

  • Oral or injectable vaccination available
  • Protection for 2-3 years

Japanese Encephalitis

Viral disease transmitted by mosquitoes in rural areas of Asia.

  • Especially during longer stays in risk areas
  • Primary immunization with 2 vaccinations

Rabies (pre-exposure prophylaxis)

Preventive rabies vaccination is advisable when:

  • Traveling to areas with high rabies risk
  • Longer stays in remote areas
  • Planned activities with animal contact

Malaria prophylaxis – no vaccine available

There is still no effective vaccine against malaria for travelers. Protection is provided by:

Exposure prophylaxis

  • Long-sleeved clothing in the evening
  • Insect repellent with DEET
  • Impregnated mosquito nets
  • Air-conditioned rooms

Chemoprophylaxis

Depending on the travel destination and duration, malaria medications can be taken prophylactically:

  • Atovaquone/Proguanil
  • Doxycycline
  • Mefloquine (in case of contraindications to other preparations)

Travel vaccinations by continents

Africa

Important vaccinations:

  • Yellow fever (often mandatory)
  • Hepatitis A and B
  • Typhoid
  • Meningococcal (Sahel zone)
  • Rabies (if in contact with animals)

Asia

Recommended vaccinations:

  • Hepatitis A and B
  • Typhoid fever
  • Japanese encephalitis (rural areas)
  • Rabies
  • Cholera (for special risks)

South America

Important vaccinations:

  • Yellow fever
  • Hepatitis A and B
  • Typhoid fever
  • Rabies

Timing: When should travel vaccinations be done?

Optimal schedule

  • 6-8 weeks before travel: Initial travel medicine consultation
  • At least 4 weeks before: Completion of all vaccinations
  • 10 days before travel: Minimum interval for yellow fever vaccination

Building immune protection

Different vaccinations require different periods until full protection:

  • Hepatitis A: 2-4 weeks
  • Yellow fever: 10 days
  • Typhoid: 1-2 weeks
  • Japanese encephalitis: 4 weeks (after 2nd vaccination)

Costs and coverage

Private health insurance

Private health insurance often fully covers the cost of travel vaccinations.

Statutory health insurance

Many statutory health insurance funds reimburse travel vaccinations as a voluntary statutory benefit:

  • Different reimbursement models
  • Often 100% cost coverage
  • Inquiry with one's own health insurance company recommended

Personal contribution

Vaccination costs vary depending on the vaccine:

  • Hepatitis A: 50-80 Euro
  • Gelbfieber: 40-60 Euro
  • Tollwut: 150-200 Euro (3 Impfungen)

Besondere Personengruppen

Schwangere Reisende

  • Lebendimpfstoffe (Gelbfieber, Typhus-Schluckimpfung) kontraindiziert
  • Inaktivierte Impfstoffe meist möglich
  • Individuelle Nutzen-Risiko-Bewertung erforderlich

Immunocompromised individuals

  • Live vaccines usually contraindicated
  • Enhanced protection with inactivated vaccines
  • Specialist medical consultation absolutely necessary

Children

  • Adapted vaccination schedule according to age
  • Some vaccinations only possible from a certain age
  • Pediatric consultation recommended

Side effects and contraindications

Common side effects

  • Local reactions (redness, swelling, pain)
  • General symptoms (fatigue, mild fever)
  • Usually harmless and self-limiting

Absolute contraindications

  • Severe immunodeficiencies (for live vaccines)
  • Severe Allergies to vaccine components
  • Acute severe illnesses

Where can you get travel vaccinations?

Travel medicine consultation centers

  • Specialized tropical medicine doctors
  • Comprehensive individual consultation
  • Up-to-date information on risk areas

General practitioners

  • Basic vaccinations usually possible
  • Limited supply of special travel vaccines
  • Referral to specialists possible

Yellow fever vaccination centers

  • Official approval for yellow fever vaccinations
  • List available at the Robert Koch Institute
  • Issuance of international vaccination certificates

Important documents and certificates

International vaccination certificate

  • Yellow card according to WHO standards
  • International recognition
  • Mandatory for yellow fever vaccination

Digital vaccination proof

  • Supplement to paper certificate
  • Not recognized in all countries
  • Backup recommended for travel

Current developments and new vaccines

The travel medicine landscape is constantly evolving. New vaccines and changing recommendations require regular updates to travel advice. Current information can be found at the Robert Koch-Institut und der German Society for Tropical Medicine.

Conclusion: Safe long-distance travel through proper vaccination

Travel vaccinations are an essential component for safe and carefree long-distance travel. Early, individualized advice from travel medicine specialists ensures optimal protection and prevents avoidable infectious diseases. Investing in travel vaccinations is an investment in your health and that of your family.

Most important tip: Start planning your vaccinations at least 6-8 weeks before your departure to have enough time for all necessary vaccinations and building up immunity.

This article does not replace individual travel medical advice. Always consult a doctor or specialized travel medical advisory service before long-distance travel.